Reversed-phase separations on cellulose tris(3,5-dimethyl phenylcarbamate)chiral stationary phase

Citation
Jg. Hou et al., Reversed-phase separations on cellulose tris(3,5-dimethyl phenylcarbamate)chiral stationary phase, CHROMATOGR, 50(1-2), 1999, pp. 89-95
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHROMATOGRAPHIA
ISSN journal
00095893 → ACNP
Volume
50
Issue
1-2
Year of publication
1999
Pages
89 - 95
Database
ISI
SICI code
0009-5893(199907)50:1-2<89:RSOCTP>2.0.ZU;2-1
Abstract
The chiral separation of eight racemic compounds has been investigated on a cellulose tris(3,5-dimethylphenylcarbamate) chiral column under reversed-p hase conditions. The discrimination mechanism under reversed-phase conditio ns is discussed. Addition of acid to the mobile phase is necessary for reso lution of acidic racemic compounds. The presence of ion-pair reagent in the mobile phase is a key factor in the resolution of basic racemic compounds. Retention of the racemates is also affected by addition of acid or salt. T he anion in buffer not only interacts wit the racemate, but also with the p olysaccharide derivative on the silica gel surface.