Cogan's syndrome: Unsuccessful outcome with early combination therapy

Interstitial keratitis and vestibulo-auditory symptoms (vertigo and hearing loss) are the typical signs of Cogan's syndrome, a rare inflammatory vascu lar disease. Signs of vasculitis in many organ systems may appear, among wh ich neurologic problems are sometime predominant. The efficacy of glucocort icoids on the ocular and systemic symptoms is established but their effect ion hearing loss is unknown. We describe a case of Cogan's syndrome with ne urological involvement in which early treatment with combination therapy (p rednisolone and cyclosporin) failed to bring ear inflammation under control .