Predictive clinical factors of very early in-hospital mortality in subarachnoid hemorrhage

This study was conducted to determine clinical predictors of very early in- hospital mortality (within the first 72 h) in patients with non-traumatic s ubarachnoid hemorrhage. Data of 184 patients with subarachnoid hemorrhage w ere obtained From consecutive stroke patients included in the prospective B arcelona Stroke Registry. Demographic, anamnestic, clinical, neurological a nd neuroimaging variables in the subgroup of patients who died within 72 h after the onset of symptoms were compared with those in the subgroup of pat ients that had survived this initial period. The independent predictive val ue of each variable on the development of very early death was assessed wit h a logistic regression analysis. Very early in-hospital death was observed in 18 patients (9.8%). These patients were significantly more likely to ha ve progressive deficit, seizures, altered consciousness, limb weakness, sen sory involvement and basal ganglia hematoma than patients without very earl y death. After multivariate analysis, only progressive deficit (odds ratio (OR) 6.90; 95% confidence interval (95% CI) 2-23.80) and limb weakness (OR 5.46; 95% CI 1.78-16.77) were independent clinical predictors of very early mortality. Progressive neurological deficit and limb weakness at the onset of stroke was independent predictive factors of very early death in patien ts with non-traumatic subarachnoid hemorrhage. These results further emphas ize the need to establish an early etiological diagnosis and to manage thes e patients aggressively including early surgery in selected cases. (C) 1999 Elsevier Science B.V. All rights reserved.