Post-transcriptional regulation of the parathyroid hormone gene by calciumand phosphate

Authors
Naveh-Many, T
Citation
T. Naveh-many, Post-transcriptional regulation of the parathyroid hormone gene by calciumand phosphate, CURR OP NEP, 8(4), 1999, pp. 415-419
Citations number
24
Categorie Soggetti
Urology & Nephrology
Journal title
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
ISSN journal
10624821 → ACNP
Volume
8
Issue
4
Year of publication
1999
Pages
415 - 419
Database
ISI
SICI code
1062-4821(199907)8:4<415:PROTPH>2.0.ZU;2-9
Abstract
Parathyroid hormone messenger RNA levels are regulated by calcium, phosphat e and 1,25-dihydroxyvitamin D-3. Dietary induced hypocalcaemia increases an d hypophosphataemia decreases parathyroid hormone mRNA levels post-transcri ptionally. This regulation is mediated by binding of parathyroid cytosolic proteins to the parathyroid hormone mRNA 3'-untranslated region, and in par ticular the terminal 60 nucleotides of the 3'-untranslated region, thereby determining RNA stability. Curr Opin Nephrol Hypertens 8:415-419. (C) 1999 Lippincott Williams & Wilkins.