Parathyroid hormone messenger RNA levels are regulated by calcium, phosphat
e and 1,25-dihydroxyvitamin D-3. Dietary induced hypocalcaemia increases an
d hypophosphataemia decreases parathyroid hormone mRNA levels post-transcri
ptionally. This regulation is mediated by binding of parathyroid cytosolic
proteins to the parathyroid hormone mRNA 3'-untranslated region, and in par
ticular the terminal 60 nucleotides of the 3'-untranslated region, thereby
determining RNA stability. Curr Opin Nephrol Hypertens 8:415-419. (C) 1999
Lippincott Williams & Wilkins.