The calcium receptor and calcimimetics

Citation
M. Wada et al., The calcium receptor and calcimimetics, CURR OP NEP, 8(4), 1999, pp. 429-433
Citations number
46
Categorie Soggetti
Urology & Nephrology
Journal title
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
ISSN journal
10624821 → ACNP
Volume
8
Issue
4
Year of publication
1999
Pages
429 - 433
Database
ISI
SICI code
1062-4821(199907)8:4<429:TCRAC>2.0.ZU;2-1
Abstract
Parathyroid cells can sense small changes in plasma Ca2+ levels by virtue o f a cell surface Ca2+ receptor. Calcimimetics are newly synthesized compoun ds that act as agonists or positive allosteric modulators at the Ca2+ recep tor and can suppress parathyroid hormone secretion. The first-generation ca lcimimetic, NPS R-568, has undergone clinical trials in primary hyperparath yroidism and in hyperparathyroidism secondary to chronic renal insufficienc y. The data accumulated so far demonstrate that calcimimetics have potentia l as therapeutic agents for hyperparathyroidism and related bone diseases s uch as osteitis fibrosa, Curr Opin Nephrol Hypertens 3:429-433. (C) 1999 Li ppincott Williams & Wilkins.