Pharmaceutical evaluation of multipurpose excipients for direct compressedtablet manufacture: Comparisons of the capabilities of multipurpose excipients with those in general use

Recently, a novel type of multipurpose excipient (MPE) with high binding ch aracteristics and high fluidity has been developed. In this study, the capa bilities of MPEs (Ludipress and Microcelac) were compared with those of exc ipients in general use. Also, the effects on powder and tableting character istics of the physical properties and contents of active ingredients were e xamined in tablets prepared with these MPEs by the direct compression metho d. Multipurpose excipients mixed with adjuvants such as fillers, binders, l ubricants, disintegrants, and the like show superior fluidity and compressi bility. Tablets containing very small amounts of highly active ingredients with little dispersion were prepared However with increases in active ingre dient content, each of the physical properties was affected strongly by the properties of the active ingredient. Tablets with appropriate hardness and disintegration characteristics could be prepared by mixing of different ty pes of MPEs.