The influence of beta-cyclodextrin on the solubility of chlorthalidone andits enantiomers

The solubility of chlorthalidone in 16 solvent systems was determined in th e absence and presence of different amounts of beta-cyclodextrin (beta-CD), Chlorthalidone (CT) was shown to be more soluble in hydrophilic organic so lvents, with the highest solubility in ethylacetate (EtOAc) saturated with water. The solubility of CT in water, butanol, octanol, and dichloromethane (DCM) was enhanced by the addition of beta-cyclodextrin. The enantioselect ive partitioning of CT between water and EtOAc, DCM, butan-1-ol, butan-2-ol , and octan-1-ol was determined in the presence of beta-CD at pH 5, 7, and 9. According to the results, both the solubility and partitioning propertie s of CT are affected by PCD in aqueous solution. It was also shown that the solubility of the individual enantiomers differs in the presence of PCD.