Design and biopharmaceutical evaluation of nitrofurantoin-loaded Eudragit RS100 micropellets

Nitrofurantoin, a synthetic bactericidal drug, was encapsulated with Eudrag it RS 100 polymer by a coacervation phase separation technique using variab le proportions of polyisobutylene (0% to 3%) as a protective colloid. The m icropellets were evaluated by scanning electron microscopy (SEM), particle size distribution, wall thickness, and loss of wall polymer were determined . The in vitro release experiments were carried our over the entire pH rang e of the gastrointestinal tract, the data obtained from the dissolution pro files were compared in the light of different kinetic models, and the regre ssion coefficients were compared. The in vivo studies were performed on fem ale human volunteers. A linear correlation was obtained from in vitro-in vi vo studies.