The dissolution and complexing properties of ibuprofen and ketoprofen whenmixed with N-methylglucamine

The objectives of this study were to improve the aqueous dissolution proper ties of the pool lv soluble nonsteroidal anti-inflammatory drugs ibuprofen and ketoprofen and to explore the use of N-methylglucamine (meglumine) to e nhance the dissolution properties of poorly water-soluble drug powders. Cha nges in both differential scanning calorimetry (DSC) and X-ray powder diffr action (XRD) results indicate that possibly complexes were produced between ibuprofen and N-methylglucamine. Similar changes were not observed for equ ivalent ketoprofen and N-methylglucamine mixtures. The results of solubilit y and dissolution studies in water at 25 degrees C and 37 degrees C showed that N-methylglucamine, in mixtures and coprecipitates, increased the solub ility, intrinsic dissolution, and powder dissolution of ketoprofen and ibup rofen. N-Methylglucamine significantly improved the solubility and dissolut ion proper ties of both ibuprofen and ketoprofen even when DSC and XRD beha vior did not indicate the formation of complexes.