Analysing the developing lymphocyte system of neonates and infants

Technical developments in immunophenotyping and function testing have great ly facilitated studies on the developing lymphocyte system in the past deca de and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-relat ed differences in lymphocyte subpopulations and function imply that the ava ilable adult reference values cannot be used in children. Conclusion In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literat ure about age-related changes in the developing lymphocyte system.