The effects of trazodone on sleep disturbances induced by brofaromine

The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO- A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofa romine and trazodone were observed and side-effects were minimal. A low dos e of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia. (C) 1999 Elsevier, Paris.