Synthesis of new phthalazinyl compounds as potential inhibitors of aldose reductase and sorbitol dehydrogenase

Chronic diabetes leads to long term complications which include neuropathy nephropathy, retinopathy and cataract. The hyperglycemia observed in diabet es results in the intracellular production of sorbitol and fructose due to an increase of the glucose flux to the polyol pathway which is regulated by 2 enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH). We envis aged the synthesis of new phthalazinyl derivatives in order to obtain compo unds inhibiting both AR and SDH.