Specific features of reactions of 2-aminobenzotrifluoride and anthranilates with ethyl cyanoacetate - Expeditious routes to 3-substituted 4-amino- and 4-hydroxyquinolin-2(1H)-ones

Simple one-pot four-step syntheses of 3-cyano-4-[2-(trifluoromethyl)phenyla mino]- (6) and 3-(4-oxo-3H-quinazolin-2-yl)-4-hydroxy- (12) quinolin-2(1H)- ones, compounds of biological importance, from commercially available start ing materials were reported. The 2-quinolinones 6 and 12 were obtained in m oderate yields by three-component reactions of 2 equivalents of 2-aminobenz otrifluoride (1, 2-(trifluoromethyl)aniline) or 2 equivalents of anthranila tes 7 with ethyl cyanoacetate (2).