Specific features of reactions of 2-aminobenzotrifluoride and anthranilates with ethyl cyanoacetate - Expeditious routes to 3-substituted 4-amino- and 4-hydroxyquinolin-2(1H)-ones
Ie. Bylov et al., Specific features of reactions of 2-aminobenzotrifluoride and anthranilates with ethyl cyanoacetate - Expeditious routes to 3-substituted 4-amino- and 4-hydroxyquinolin-2(1H)-ones, HETEROCYC C, 5(3), 1999, pp. 281-284
Simple one-pot four-step syntheses of 3-cyano-4-[2-(trifluoromethyl)phenyla
mino]- (6) and 3-(4-oxo-3H-quinazolin-2-yl)-4-hydroxy- (12) quinolin-2(1H)-
ones, compounds of biological importance, from commercially available start
ing materials were reported. The 2-quinolinones 6 and 12 were obtained in m
oderate yields by three-component reactions of 2 equivalents of 2-aminobenz
otrifluoride (1, 2-(trifluoromethyl)aniline) or 2 equivalents of anthranila
tes 7 with ethyl cyanoacetate (2).