Angiomyofibroblastoma - A clinicopathologic study of eight cases and review of the literature

We report the clinicopathologic features of eight new cases of angiomyofibr oblastoma and review the literature on this recently described entity. Most of our female patients had a vulvar mass that clinically was thought to be a Bartholin's gland cyst. The tumors were well circumscribed and measured 2.9 to 11 cm (mean, 5.2 cm). No recurrences or metastases were observed dur ing follow-up, which ranged from 2 months to 4 years. The turners were char acterized by a myxomatous background with prominent vessels surrounded by p lump stromal cells. Immunohistochemically, the stromal cells were reactive for vimentin, but staining for desmin was not always present. Angiomyofibro blastoma should be distinguished from aggressive angiomyxoma because the tw o entities behave differently. Morphologic and immunohistochemical features should also be considered.