Toxicity of fatty acid 18 : 5n3 from Gymnodinium cf. mikimotoi: I. Morphological and biochemical aspects on Dicentrarchus labrax gills and intestine

Authors
Sola, F Masoni, A Fossat, B Porthe-Nibelle, J Gentien, P Bodennec, G
Citation
F. Sola et al., Toxicity of fatty acid 18 : 5n3 from Gymnodinium cf. mikimotoi: I. Morphological and biochemical aspects on Dicentrarchus labrax gills and intestine, J APPL TOX, 19(4), 1999, pp. 279-284
Citations number
29
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF APPLIED TOXICOLOGY
ISSN journal
0260437X → ACNP
Volume
19
Issue
4
Year of publication
1999
Pages
279 - 284
Database
ISI
SICI code
0260-437X(199907/08)19:4<279:TOFA1:>2.0.ZU;2-S
Abstract
We present evidence for the toxic effects of fatty acid 18:5n3 (octadecapen taenoic acid) in the gills and intestine of the sea bass Dicentrarchus labr ax, Light microscopic observation of gills showed strong mucus production a nd alteration of ionocytes, The Mg- and Na,K-ATPase activities were inhibit ed, with IC50 values of 10(-3) and 1.6 x 10(-4) M, respectively. Results ar e discussed in relation to osmoregulation. Copyright (C) 1999 John Wiley & Sons, Ltd.