Cytotoxic lignans of Justicia ciliata

Citation
Sh. Day et al., Cytotoxic lignans of Justicia ciliata, J NAT PROD, 62(7), 1999, pp. 1056-1058
Citations number
10
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
7
Year of publication
1999
Pages
1056 - 1058
Database
ISI
SICI code
0163-3864(199907)62:7<1056:CLOJC>2.0.ZU;2-J
Abstract
Two new naturally occurring 1-aryl-2,3-naphthalide lignans, cilinaphthalide A (1) and cilinaphthalide B (2), and nine known compounds were isolated fr om the whole plant of Justicia ciliata. Their structures were established b y spectral analysis, and their cytotoxic activity was evaluated against sev eral different cell lines. The known compound, justicidin A, showed potent cytotoxic effects against T-24, CaSki, SiHa, HT-3, PLC/PRF/5, and 212 cells in vitro.