MEMBRANE TOPOLOGY OF THE METAL-TETRACYCLINE H+ ANTIPORTER TETA(K) FROM STAPHYLOCOCCUS-AUREUS/

Authors
GINN SL BROWN MH SKURRAY RA
Citation
Sl. Ginn et al., MEMBRANE TOPOLOGY OF THE METAL-TETRACYCLINE H+ ANTIPORTER TETA(K) FROM STAPHYLOCOCCUS-AUREUS/, Journal of bacteriology, 179(11), 1997, pp. 3786-3789
Citations number
27
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
179
Issue
11
Year of publication
1997
Pages
3786 - 3789
Database
ISI
SICI code
0021-9193(1997)179:11<3786:MTOTMH>2.0.ZU;2-F
Abstract
A series of fusions to the reporter proteins alkaline phosphatase and beta-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-med iated tetracycline resistance in Staphylococcus aureus. The results su pport a topological model of 14 transmembrane segments for TetA(K).