Detection of ultra-early brain damage after acute subdural hematoma in therat by magnetic resonance imaging

Citation
E. Tsuchida et al., Detection of ultra-early brain damage after acute subdural hematoma in therat by magnetic resonance imaging, J NEUROTRAU, 16(7), 1999, pp. 595-602
Citations number
29
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROTRAUMA
ISSN journal
08977151 → ACNP
Volume
16
Issue
7
Year of publication
1999
Pages
595 - 602
Database
ISI
SICI code
0897-7151(199907)16:7<595:DOUBDA>2.0.ZU;2-E
Abstract
We measured serial changes in diffusion-weighted magnetic resonance imaging (DW) and in apparent diffusion coefficient (ADC) 1 to 3 hours after induct ion of acute subdural hematoma (ASDH) in rats, to assess the rate of develo pment of cytotoxic edema and ischemic brain damage observed in this model. Cortical ADC values underneath the hematoma in ASDH rats (n = 12) were sign ificantly lower than those in sham-operated rats (n = 5) at 1 hour. By 3 ho urs, the area of ADC abnormality had further increased. The lesion areas, a s percentage of hemispheric areas on 1- and 3-hour ADC maps, correlated sig nificantly with those on the histologic sections stained with hematoxylin a nd eosin, The results indicate that DWI with ADC mapping may provide a valu able diagnostic tool for monitoring of early pathologic changes following s ubdural hematoma in head-injured patients.