Inhibitory effect of ferulic acid and isoferulic acid on the production ofmacrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells
S. Sakai et al., Inhibitory effect of ferulic acid and isoferulic acid on the production ofmacrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells, MEDIAT INFL, 8(3), 1999, pp. 173-175
WE investigated the effect of ferulic acid (FA) and isoferulic acid (IFA),
which are the main active components of the rhizoma of Cimicifuga heracleif
olia (CH), an anti-inflammatory drug used frequently in Japanese traditiona
l medicine, on the production of macrophage inflammatory protein-2 (MIR-2)
in a murine macrophage cell line, RAW264.7, in response to respiratory sync
ytial virus (RSV) infection, Following the exposure of cells to RSV for 20
h, the MIP-2 level in condition medium was increased to about 20 ng/ml, alt
hough this level in mock-infected cells was negligible, In the presence of
either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dep
endent manner, These data suggest that FA and IFA might be responsible, at
least in part, for the anti-inflammatory drug effect of CH extract through
the inhibition of MIP-2 production.