We have studied the ability of oleoyl-lysophosphatidic acid (O-LPA) to indu
ce a synergistic platelet aggregatory response with the following agents: A
DP, noradrenaline (NA), thrombin receptor agonist peptide (TRAP1-6), arachi
donic acid (AA), phorbol 12-myristate 13-acetate (PMA), Ca2+ ionophore A23,
187 and sodium fluoride (NaF). O-LPA mediated synergism with the aggregatin
g agents (ADP, noradrenaline and TRAP1-6) which mediate their aggregatory r
esponses through platelet membrane-bound receptors. Arachidonic acid also f
alls into the above group, as the platelet aggregation mediated by this fat
ty acid is through the synthesis of thromboxane A, which binds to its own p
latelet cell membrane receptor. O-LPA reduced the response time of platelet
s to both PMA and the Ca2+ ionophore A23,187 with minimum effect on the tot
al percentage aggregation. Finally, O-LPA appeared not to synergise with Na
F. Med Sci Res 27:435-441 (C) 1999 Lippincott Williams & Wilkins.