Hepatitis B virus transgenic mouse model of chronic liver disease

Authors
Larkin, J Clayton, M Sun, B Perchonock, CE Morgan, JL Siracusa, LD Michaels, FH Feitelson, MA
Citation
J. Larkin et al., Hepatitis B virus transgenic mouse model of chronic liver disease, NAT MED, 5(8), 1999, pp. 907-912
Citations number
42
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
5
Issue
8
Year of publication
1999
Pages
907 - 912
Database
ISI
SICI code
1078-8956(199908)5:8<907:HBVTMM>2.0.ZU;2-6
Abstract
A model for hepatitis B virus-associated chronic liver disease has been mad e using cloned hepatitis B virus DNA as a transgene in a severe combined im munodeficient host. These mice consistently support virus gene expression a nd replication. After adoptive transfer of unprimed, syngeneic splenocytes, these mice cleared virus from liver and serum, and developed chronic liver disease. This model will permit identification of the host and virus contr ibutions to chronic liver disease in the absence of tolerance.