Follow up of workers previously exposed to silver solder containing cadmium

Objectives-To study longitudinal biological monitoring data on urinary and blood cadmium collected in a small cohort of nine workers who had been braz ing for several years with solders containing cadmium. Methods-Cadmium was measured by neutron activation analysis in livers and k idneys, and estimates of renal function were carried out in 1983 and 1995. During the intervening period exposure to cadmium was dramatically reduced by local exhaust ventilation control and substitution of the solder contain ing cadmium. Results-From urinary protein measurements there was evidence within the gro up of increasing renal tubular damage over the 12 year period, even though exposure to cadmium was dramatically reduced over this period and almost el iminated by 1995. There was no evidence from serum creatinine of decreasing glomerular filtration rate, and the renal tubular handling of calcium, pho sphate, or urate had not worsened significantly. Blood and urinary cadmium concentrations reduced significantly over the 12 year period but were still substantial in 1995. Blood cadmium concentrations tended to reflect cadmiu m body burden in 1995 when exposure had been low for several years, and dec reased most significantly during 1983-90. By contrast urinary cadmium conce ntrations only decreased significantly from about 1990 onwards. Urinary cad mium was not significantly correlated with liver or kidney cadmium concentr ation in either 1983 or 1995. This may be due to the level of tubular dysfu nction in the cohort. Calculated cumulative excretion of cadmium over the 1 2 year period was substantially greater than the loss of cadmium measured i n Livers and kidneys and the derived loss in body burden. Reasons for this are discussed. It is possible that in cohorts, where renal damage is appare nt, urinary concentrations reflect a substantial component of current expos ure rather than stored body losses. Conclusions-The data reinforce the concept that blood cadmium concentration s may not always reflect recent exposure, but may reflect body burden deriv ed from historical exposure depending on the degree of current exposure; an d that the decline in urinary and blood cadmium measurements after removal from, or reduction in, exposure will be slow and depend on the historical b ody burden.