Application of modified flavone closure for the preparation of racemic L86-8275

Authors
Tabaka, AC Murthi, KK Pal, K Teleha, CA
Citation
Ac. Tabaka et al., Application of modified flavone closure for the preparation of racemic L86-8275, ORG PROC R, 3(4), 1999, pp. 256-259
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
3
Issue
4
Year of publication
1999
Pages
256 - 259
Database
ISI
SICI code
1083-6160(199907/08)3:4<256:AOMFCF>2.0.ZU;2-H
Abstract
The laboratory preparation of racemic L86-8275 (la) and the salt (Ib) is de scribed in 7% overall yield. Our method eliminated a number of chromatograp hy steps from the patent procedure and improved the flavone-forming reactio n by employing a stepwise mechanism. Solvent-free conditions for the demeth ylation step are also described.