Comprehensive kinetic screening of catalysts using reaction calorimetry

The protocol based on reaction calorimetry which is described in this paper offers a multidimensional kinetic and stability profile of a catalyst cand idate in liquid and multiphase reactions. The scale-transparent picture of catalyst properties provided by this method should make it generally useful for rapid screening of candidates for catalytic process steps as well as f or fundamental kinetic and mechanistic studies of organic reactions. In the example described here, new Pd complexes with nitrogen-based ligands were found to be more active than phosphapalladacycles in the Heck coupling of a ryl halides with olefins.