The aim of this overview was to identify interventions that change doctor p
rescribing behaviour and to derive conclusions for practice and further res
earch. Relevant studies (indicating prescribing as a behaviour change) were
located from a database of studies maintained by the Cochrane Collaboratio
n on Effective Professional Practice. This register is kept up to date by s
earching the following databases for reports of relevant research: DHSS-DAT
A; EMBASE; MEDLINE; SIGLE; Resource Database in Continuing Medical Educatio
n (1975-1994), along with bibliographies of related topics, hand searching
of key journals and personal contact with content area experts. Randomised
controlled trials and non-equivalent group designs with pre- and post-inter
vention measures were included. Outcome measures were those used by the stu
dy authors. For each study we determined whether these were positive, negat
ive or inconclusive. Positive studies (+) were those that demonstrated a st
atistically significant change in the majority of outcomes measured at leve
l of p less than or equal to 0.05 between the intervention and control grou
ps. Negative studies (-) showed a significant change in the opposite direct
ion and inconclusive studies (approximate to) showed no significant change
compared to control or no overall positive findings. We identified 79eligib
le studies which described 96 separate interventions to change prescribing
behaviour. Of these interventions, 49 (51%, 41%-61%) showed a positive sign
ificant change compared to the control group but interpretation of specific
interventions is limited due to wide and overlapping confidence intervals.