Synthesis, reactions and biological activity of some new thieno[2,3-f]-1,3-benzodioxoles

The reaction of 7-chlorothieno[2,3-f]-1,3-benzodioxole-6-carbonyl chloride (2) with some aromatic or heterocyclic amines gave the corresponding 6-(ary l or heterocyclyl) carbamoyl-7-chlorothieno [2,3-f]-1,3-benzodioxoles (3a-c , 4a, b and 5). Compound 2 was also reacted with potassium thiocyanate, eth anol or sodium azide to afford the isothiocyanto compound 6, the ester 7 an d the acid azide 9, respectively. Hydrazinolysis of 7 gave the carbohydrazi de 8. The compounds 6, 8 and 9 were used as precursors in the synthesis of the target heterocycles, 7-chlorothieno[2,3-f]-1,3-benzodioxoles substitute d with a variety of moieties at position-6 (10-15, 17, 19-26, 28-31). Also, 2-methyl-1,3-dixolo[5,6][1]benzothieno[2.3-c]quinolin-6(5 H)-one (33) was prepared. The antibacterial and antifungal activities of some selected comp ounds were also reported.