MP84 EXPRESSION IN THE URINE - SPECIMENS OF ACUTE REJECTION RENAL-TRANSPLANT RECIPIENTS

MP84 is a novel protein synthesized in response to all cytokines. This antigen is expressed only in stimulated mesangial cells and decreased kidney sections, but nor in the normal kidney sections (1,2). This st udy was performed to determine the excretion of MP84 in the urine of r enal transplant recipients with acute rejection. Six persons with rena l transplant acute rejection and 10 healthy persons were included. Two urine specimens from each person were collected. Dot-blot assay was p erformed. It was shown that 12 urine specimens from 6 persons with acu te ejection revealed MP84 in the matrix dot-blot assay while there was no staining for MP84 in the urine specimens of healthy persons. This could be due to the immunological alteration during the acute rejectio n which could lead to autocrine and paracrine secretion of growth fact ors and then the excretion of MP84 in the urine. The mechanism of MP84 secretion is not clear.