A 3D volume overlap algorithm has been developed for converting energy depo
sition kernels between arbitrary 2D and 3D irradiation geometries. The kern
els can be used as convolution kernels in inverse radiation therapy plannin
g and as accurate descriptions of the dose distributions for clinically imp
ortant beam geometries. The new method of dose calculation combining Monte
Carlo and analytical methods has introduced an improved accuracy in dose ca
lculation on the fractional per cent level. The comparisons are also made f
or a wide range of photon spectra and irradiation geometries from narrow po
int monodirectional pencil beams to finite uniform beams, 4 pi steradians i
sotropically converging beams and divergent beams from isotropic point sour
ces. It is seen that the photon scatter penumbra is highest at low photon e
nergies whereas the secondary electron penumbra is widest at high photon en
ergies, making low energy beams more interesting for small targets and high
energy beams most useful for large deep-seated targets.