The uptake of cerium by erythrocytes and the changes of membrane permeability in CeCl3 feeding rats

During the course of feeding CeCl3 to Wistar rats, the temporal changes of cerium content in cytosol and membrane of erythrocytes were determined by p roton induced X-ray emission method. The results showed that the cerium spe cies can penetrate the barriers in digestive duct and erythrocyte membrane into the cells, and the increased intracellular levels of calcium and chlor ide and the decreased phosphorus level along with the entry of cerium are a lso revealed. It suggests the cerium species affect the permeability of ery throcyte membrane, and the intracellular cerium promotes the hydrolysis of phosphate diester bonds of the phorsphates, such as 2, 3-DPG, etc. The mech anisms of across-membrane transport of cerium are also discussed.