On the myth of antibrain antibodies in schizophrenia - a critical overview

Antibrain antibodies are regarded as a hallmark of an autoimmune process in schizophrenia. The literature, however, is contradictory to a large extent . Furthermore, the older studies used now outdated methodology. The modern studies using Western and Immunoblot technique were greatly negative. Our o wn results on the occurrence of antibrain antibodies in schizophrenia were disappointing over the last years. In the present study we investigated ant ibody binding in serum from schizophrenic patients to the nuclear, membrane and water soluble protein fractions from human brain by Western and Immuno blot. There were no specific results. Therefore, we conclude that there is at present no proof of antibrain antibodies in schizophrenia.