T cell subsets and expression of integrins in peripheral blood of patientswith migraine and chronic tension type headache

Neurogenic inflammation of dural Vessels has been hypothesised to be an ess ential part of migraine physiopathology. Analysis of lymphocyte subpopulati ons and integrin expression in the peripheral blood of headache patients (m igraine and chronic tension type headache) showed an elevated proportion of T-helper cells and T-helper memory cells as well as a higher expression of LFA-1 on T-helper and T-suppressor cells. This could be a sign of enhanced endothelium and lymphocyte interaction as it would be expected in an infla mmatory process of cranial vessels.