Albumin adsorption on stealth and non-stealth solid lipid nanoparticles

Two series of sterically stabilized (stealth) solid lipid nanoparticles wer e prepared from bioacceptable components using two polyethylene glycol (PEG ) derivatives: dipalmitoylphosphatidylethanolamine conjugated with PEG 2000 (DPPE/PEG) and stearic acid conjugated with PEG 2000 (stearate/PEG). Steal th solid lipid nanoparticles were in the nanometer size range and could be freeze-dried; average diameter polydispersity index and zeta potential were determined. The amount of human serum albumin adsorbed on stealth and non- stealth solid lipid nanoparticles was also established. Albumin adsorption was lower on stealth than on non-stealth solid lipid nanoparticles. Stearat e/PEG 2000 gave better steric protection of nanoparticles than did dipalmit oylphosphatidylethanolamine/PEG 2000.