N-2-acetyl-O-6-(2-(p-nitrophenyl)ethyl)guanine: A convenient building block for the synthesis of 9-substituted guanine derivatives

Authors
Zhou, JL Tsai, JY Bouhadir, K Shevlin, PB
Citation
Jl. Zhou et al., N-2-acetyl-O-6-(2-(p-nitrophenyl)ethyl)guanine: A convenient building block for the synthesis of 9-substituted guanine derivatives, SYN COMMUN, 29(17), 1999, pp. 3003-3009
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
17
Year of publication
1999
Pages
3003 - 3009
Database
ISI
SICI code
0039-7911(1999)29:17<3003:NACBB>2.0.ZU;2-8
Abstract
Readily accessible N-2-acetyl-O-6-(2-(p-nitrophenyl)ethyl)guan can undergo Mitsunobu reactions with either a primary or secondary alcohol to generate guanine derivatives. X-ray data indicates that only the desired 9-subsitute d derivatives of guanine are formed.