Solid-phase synthesis of unnatural alpha-amino acid derivatives using a resin-bound glycine cation equivalent

Authors
O'Donnell, MJ Delgado, F Drew, MD Pottorf, RS Zhou, CY Scott, WL
Citation
Mj. O'Donnell et al., Solid-phase synthesis of unnatural alpha-amino acid derivatives using a resin-bound glycine cation equivalent, TETRAHEDR L, 40(32), 1999, pp. 5831-5835
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
32
Year of publication
1999
Pages
5831 - 5835
Database
ISI
SICI code
0040-4039(19990806)40:32<5831:SSOUAA>2.0.ZU;2-A
Abstract
Unnatural amino acids were synthesized on solid-phase by reaction of a resi n-bound Schiff base with organoboranes. This novel use of a resin-bound gly cine cation equivalent allows for the preparation of a variety of amino aci d structural types not readily available by the complementary anionic equiv alent. (C) 1999 Elsevier Science Ltd. All rights reserved.