Synthesis of benzo[5 ',6 '] cyclohepta[4,5]pyrrolo[2,3-b]pyridin-12-one

Authors
Mouaddib, A Joseph, B Hasnaoui, A Merour, JY
Citation
A. Mouaddib et al., Synthesis of benzo[5 ',6 '] cyclohepta[4,5]pyrrolo[2,3-b]pyridin-12-one, TETRAHEDR L, 40(32), 1999, pp. 5853-5854
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
32
Year of publication
1999
Pages
5853 - 5854
Database
ISI
SICI code
0040-4039(19990806)40:32<5853:SOB''C>2.0.ZU;2-A
Abstract
The synthesis of a 7-azaindole derivative 8 with potential antitumoral acti vity is described starting from pyrrolo[2,3-b]pyridine; regioselective lith iation/methylation of alkyl 7-azaindole-3-carboxylates 4 afforded the 2-met hyl derivatives 5. Demethylation of eater 6a using BBr3 afforded the acid 7 , which is cyclised into the tetracyclic derivative 8. (C) 1999 Published b y Elsevier Science Ltd. All rights reserved.