Signalling through the JAK-STAT pathway in the developing brain

Citation
E. Cattaneo et al., Signalling through the JAK-STAT pathway in the developing brain, TRENDS NEUR, 22(8), 1999, pp. 365-369
Citations number
82
Categorie Soggetti
Neurosciences & Behavoir
Journal title
TRENDS IN NEUROSCIENCES
ISSN journal
01662236 → ACNP
Volume
22
Issue
8
Year of publication
1999
Pages
365 - 369
Database
ISI
SICI code
0166-2236(199908)22:8<365:STTJPI>2.0.ZU;2-C
Abstract
The JAK-STAT (Janus kinase-signal transducer and activator of transcription ) signalling pathway that is stimulated by cytokines has been much investig ated in haematopoietic cells, but recent data indicate that this pathway is also present and active during neuronal and glial differentiation. Further more, it is now clear that growth factors other than the classical cytokine s can act through this pathway and that physiological inhibitors of this si gnalling cascade exist. Thus, the JAKs, the STATs and their specific inhibi tors could be molecules with important roles in the CNS.