The sudden death of two horses was attributed to the rapid and acute develo
pment of pulmonary aspergillosis. One horse was making excellent postoperat
ive progress after a jejunal resection and anastomosis for intestinal adhes
ions. The other horse was being treated routinely for equine protozoal myel
oencephalitis (EPM). Signs of fever and an increased respiratory rate were
detected shortly before death in the first horse, but no premonitory clinic
al signs characteristic of pulmonary infection were detected in the horse b
eing treated for EPM. Both horses developed rapidly debilitating, acute pul
monary mycosis and died unexpectedly.