Design, syntheses and biological activity of novel herbicides targeting ALS - VIII. Studies on structure-activity relationships of fused heterocyclicsulfonamide herbicides combined Hansch analyses and CoMFA method

Two dimensional and three dimensional structure - activity relationships of herbicidal triazolopyrimidinyl sulfonamides were studied using Hansch and CoMFA method. The results show that the electronic property and stereo - st ructure have an important impact on the herbicidal activity. A suitable aci dity and steric effect were required for higher activity. Furthermore,the s tudies also indicate that application Hansch and CoMFA method simultaneousl y can reflect more completely the structure activity relationships of drug molecules.