The clinicopathological significance of p21 and p53 expression in esophageal squamous cell carcinoma: An analysis of 153 patients

OBJECTIVE: The p21 gene is thought to play a central role in tumor suppress ion. The aim of this study was to examine the clinicopathological role of p 21 and p53 in esophageal squamous cell carcinomas. METHODS: The expression of p21 and p53 proteins in 153 Chinese patients (13 1 men, 22 women) with resected esophageal squamous cell carcinomas was inve stigated by the immunohistochemical method. Correlation between p21 and p53 expression and clinicopathological features was examined. RESULTS: The expression of p21 and p53 was detected in 70% and 64% of the t umors, respectively. The staining of p21 and p53 was also found in squamous carcinoma in situ, dysplasia, and nontumor epithelium. p21 expression was often weak in the suprabasal cells and found in better differentiated tumor s. There was no significant correlation between the expression of p21 and t he abnormal accumulation of p53. The prognosis of the patients depended on the size, stage, and p21 expression of the lesion. In stage III lesions wit h tumor diameter less than or equal to 7.5 cm (n = 93), patients with loss of p21 expression had better survival. The survival rates of patients were worse if they had expression of both p21 and p53. CONCLUSIONS: Thus, p21 and p53 had prognostic value for esophageal squamous cell carcinomas. Loss of p21 expression was shown without p53 alternations , indicating that other mechanisms are also involved in turning off the gen e. The pattern of p21 and p53 expression predicts an aggressive clinical co urse of esophageal squamous cell carcinomas. (Am J Gastroenterol 1999;94:20 60-2068. (C) 1999 by Am. Coll. of Gastroenterology).