Amitriptyline absorption in a patient with short bowel syndrome

Citation
B. Robbins et Ra. Reiss, Amitriptyline absorption in a patient with short bowel syndrome, AM J GASTRO, 94(8), 1999, pp. 2302-2304
Citations number
9
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
AMERICAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
00029270 → ACNP
Volume
94
Issue
8
Year of publication
1999
Pages
2302 - 2304
Database
ISI
SICI code
0002-9270(199908)94:8<2302:AAIAPW>2.0.ZU;2-E
Abstract
Oral drug therapy in patients with short bowel syndrome can be quite challe nging. We report the case of a 40-yr-old woman with short bowel syndrome an d depression requiring antidepressant drug therapy. After buccal administra tion of amitriptyline, therapeutic serum antidepressant concentrations were attained despite the patient having only 18 inches of proximal small bowel . Clinical improvement in mood was seen, with the only drug side effects be ing dry mouth and bitter drug taste. Buccal absorption likely is playing a major role in attaining therapeutic serum tricyclic antidepressants drug co ncentrations. (Am J Gastroenterol 1999;94:2302-2304. (C) 1999 by Am. Coll. of Gastroenterology).