Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenesclinical isolates with alterations in GyrA and ParC proteins

Authors
Brisse, S Milatovic, D Fluit, AC Verhoef, J Martin, N Scheuring, S Kohrer, K Schmitz, FJ
Citation
S. Brisse et al., Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenesclinical isolates with alterations in GyrA and ParC proteins, ANTIM AG CH, 43(8), 1999, pp. 2051-2055
Citations number
21
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
8
Year of publication
1999
Pages
2051 - 2055
Database
ISI
SICI code
0066-4804(199908)43:8<2051:CIVAOC>2.0.ZU;2-U
Abstract
The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levo floxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxa cin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneum oniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes . Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K . pneumoniae and E. aerogenes.