Hydroxyurea enhances the activities of didanosine, 9-[2(phosphonylmethoxy)ethyl] adenine, and 9-[2(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates

Authors
Palmer, S Shafer, RW Merigan, TC
Citation
S. Palmer et al., Hydroxyurea enhances the activities of didanosine, 9-[2(phosphonylmethoxy)ethyl] adenine, and 9-[2(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates, ANTIM AG CH, 43(8), 1999, pp. 2046-2050
Citations number
38
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
8
Year of publication
1999
Pages
2046 - 2050
Database
ISI
SICI code
0066-4804(199908)43:8<2046:HETAOD>2.0.ZU;2-Y
Abstract
We assessed the effects of hydroxyurea (HU) at a concentration of 50 mu M o n the in vitro activities of 2',3'-dideoxyinosine (ddI), 9-[2-(phosphonylme thoxy)ethyl]adenine (PMEA), and 9-[2-(phosphonylmethoxy)propyl]adenine (PMP A) against a wild-type human immunodeficiency virus (HIV) type 1 (HIV-1) la boratory isolate and a panel of five well-characterized drug-resistant HIV isolates. Fifty micromolar HU significantly increased the activities of ddI , PMEA, and PMPA against both the wild-type and the drug-resistant HIV-1 is olates. In fixed combinations, both ddI and PMEA were synergistic with HU a gainst wild-type and drug-resistant viruses.