A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2 ',3 '-dideoxy-3 '-thiacytidine

Authors
Smith, RA Klarmann, GJ Stray, KM von Schwedler, UK Schinazi, RF Preston, BD North, TW
Citation
Ra. Smith et al., A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2 ',3 '-dideoxy-3 '-thiacytidine, ANTIM AG CH, 43(8), 1999, pp. 2077-2080
Citations number
46
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
8
Year of publication
1999
Pages
2077 - 2080
Database
ISI
SICI code
0066-4804(199908)43:8<2077:ANPM(I>2.0.ZU;2-J
Abstract
A P157S mutation in the reverse transcriptase (RT) of human immunodeficienc y virus type 1 conferred fivefold resistance to (-)-beta-2',3'-dideoxy-3'-t hiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'-deoxythymidine (AZ T) and to (R)-9-(2-phosphonylmethoxypropyl) adenine (PMPA). A similar incre ase in susceptibility to AZT and to PMPA was also conferred by the M184V mu tation in RT.