A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2 ',3 '-dideoxy-3 '-thiacytidine
Ra. Smith et al., A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2 ',3 '-dideoxy-3 '-thiacytidine, ANTIM AG CH, 43(8), 1999, pp. 2077-2080
A P157S mutation in the reverse transcriptase (RT) of human immunodeficienc
y virus type 1 conferred fivefold resistance to (-)-beta-2',3'-dideoxy-3'-t
hiacytidine in cell culture. Interestingly, the P157S mutation resulted in
increased sensitivity (two- to threefold) to 3'-azido-3'-deoxythymidine (AZ
T) and to (R)-9-(2-phosphonylmethoxypropyl) adenine (PMPA). A similar incre
ase in susceptibility to AZT and to PMPA was also conferred by the M184V mu
tation in RT.