Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (Ports)

Citation
Tu. Anthony et Lg. Rubin, Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (Ports), ANTIM AG CH, 43(8), 1999, pp. 2074-2076
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
8
Year of publication
1999
Pages
2074 - 2076
Database
ISI
SICI code
0066-4804(199908)43:8<2074:SOAUFA>2.0.ZU;2-0
Abstract
Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lume n of the catheter or port. We tested the stability of vancomycin, cefazolin , ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37 degrees C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime re tained greater than or equal to 90% activity at both 25 and 37 degrees C. T hus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.