Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection

Several organosilicon and organogermanium compounds possessing radioprotect ive activity have been synthesized, In this paper, we describe the preparat ion and study of the pharmacological properties of new organometallic compo unds such as metallathiazolidines and metalladithioacetals derived from 1-[ N-(2-mercaptoethyl)-2-aminoethyl]-2-(1-naphthylmethyl)-2-imidazoline and 1- [N-(2-mercaptopropyl)-2-aminoethyl]-2-(1-naphthylmethyl)-2-imidazoline. We have noted a decrease in the toxicity and a rather important increase in th e radioprotective activity of these new organometallic derivatives in compa rison with the starting organic compounds, Copyright (C) 1999 John Wiley & Sons, Ltd.