Mammalian phospholipase D structure and regulation

Authors
Frohman, MA Sung, TC Morris, AJ
Citation
Ma. Frohman et al., Mammalian phospholipase D structure and regulation, BBA-MOL C B, 1439(2), 1999, pp. 175-186
Citations number
83
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
ISSN journal
13881981 → ACNP
Volume
1439
Issue
2
Year of publication
1999
Pages
175 - 186
Database
ISI
SICI code
1388-1981(19990730)1439:2<175:MPDSAR>2.0.ZU;2-3
Abstract
The recent identification of cDNA clones for phospholipase D1 and 2 has ope ned the door to new studies on its structure and regulation. PLD activity i s encoded by at least two different genes that contain catalytic domains th at relate their mechanism of action to phosphodiesterases. In vivo roles fo r PLD suggest that it may be important for multiple specialized steps in re ceptor dependent and constitutive processes of secretion, endocytosis, and membrane biogenesis. (C) 1999 Elsevier Science B.V. All rights reserved.