Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans - Preliminary results in patients with idiopathic calcium urolithiasis
U. Herrmann et al., Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans - Preliminary results in patients with idiopathic calcium urolithiasis, BIOMED PHAR, 53(5-6), 1999, pp. 264-273
Calcium, in the form of regular food supplementation, can improve bone meta
bolism, but it can also increase the risk for renal calcium stones, and may
aggravate pre-existing calcium urolithiasis. To study the first of these t
wo aspects, ten healthy volunteers were given a conventional test meal (bre
akfast; calcium content 28 mg) with or without two dosages of calcium (as c
alcium-sodium citrate, CSC 1, 680 mg; CSC 2 1,360 mg), taken after an overn
ight 12 h fast. To study the latter aspect, patients with idiopathic recurr
ent calcium urolithiasis (ICU) received a balanced test meal of fixed compo
sition, containing 1,000 mg calcium either as CSC (Mcal + CSC3; n = 6) or a
s calcium gluconate (Mcal; n = 8). In normals, CSC induced a dose-dependent
increasing intestinal absorption of calcium, and a decrease in oxalate abs
orption; in serum, CSC increased calcitonin and suppressed parathyroid horm
one, but left unchanged the markers of bone turnover, serum osteocalcin and
bone alkaline phosphatase. In urine, CSC decreased bone resorption markers
(collagen crosslinks) and phosphaturia increased citrate, created signs of
metabolic alkalosis, and inhibited several parameters of CaOx crystallizat
ion. In ICU, the CSC3 load failed to promote the crystallization of CaOx an
d calcium phosphate. It was concluded that CSC supplementation of a meal: (
1) is well tolerated by healthy subjects and ICU patients, renders calcium
highly available to bone, and prevents post-prandial oxaluria from rising;
and, (2) is followed by the inhibition of crystallization of renal stone fo
rming calcium-containing substances. Long-term studies aimed at evaluating
the usefulness of CSC in preserving healthy bone, and in the metaphylaxis o
f renal stones would appear justified. (C) 1999 Elsevier, Paris.