Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping

Authors
Brouillette, WJ Atigadda, VR Luo, M Air, GM Babu, YS Bantia, S
Citation
Wj. Brouillette et al., Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping, BIOORG MED, 9(14), 1999, pp. 1901-1906
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
1901 - 1906
Database
ISI
SICI code
0960-894X(19990719)9:14<1901:DOBAIO>2.0.ZU;2-Q
Abstract
A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effecti vely replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzo ic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors. (C) 1999 Elsevier Science Ltd. All rights reserved.