Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

Authors
Duffy, KJ Ridgers, LH DesJarlais, RL Tomaszek, TA Bossard, MJ Thompson, SK Keenan, RM Veber, DF
Citation
Kj. Duffy et al., Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K, BIOORG MED, 9(14), 1999, pp. 1907-1910
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
1907 - 1910
Database
ISI
SICI code
0960-894X(19990719)9:14<1907:DASODI>2.0.ZU;2-Q
Abstract
The structure-based design and synthesis of lactam-constrained azapeptide i nhibitors of human cathepsin K are described. Enhanced stability to proteol ytic cleavage over acyclic analogues is discussed. (C) 1999 Elsevier Scienc e Ltd. All rights reserved.