The design and synthesis of ALS inhibitors from pharmacophore models

In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore mod els, which provided information to design novel molecules by 3D-database se arching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities. (C) 1999 Elsevier Science Ltd. All rights r eserved.